Desensitization of patients with a high cPRA who are in need of a kidney transplant.

My topic of research is the intervention is a desensitization program and the measurable outcome could be antibody clearance for a specified period of time. Desentisitization of transplant candidtes with high cPRA. 

The critical appraisal process utilizes formal appraisal tools to assess the results of research to determine value to the context at hand. Evidence-based practitioners often present these findings to make the case for specific courses of action.

In this Assignment, you will use an appraisal tool to conduct a critical appraisal of published research. You will then present the results of your efforts.The critical appraisal process utilizes formal appraisal tools to assess the results of research to determine value to the context at hand. Evidence-based practitioners often present these findings to make the case for specific courses of action.
In this Assignment, you will use an appraisal tool to conduct a critical appraisal of published research. You will then present the results of your efforts.The critical appraisal process utilizes formal appraisal tools to assess the results of research to determine value to the context at hand. Evidence-based practitioners often present these findings to make the case for specific courses of action.
In this Assignment, you will use an appraisal tool to conduct a critical appraisal of published research. You will then present the results of your efforts. To Prepare:
Reflect on the four peer-reviewed articles you selected in Module 2 and the four systematic reviews (or other filtered high- level evidence) you selected in Module 3.
Reflect on the four peer-reviewed articles you selected in Module 2 and analyzed in Module 3.
Review and download the Critical Appraisal Tool Worksheet Template provided in the Resources.
The Assignment (Evidence-Based Project)
Part 3A: Critical Appraisal of Research
Conduct a critical appraisal of the four peer-reviewed articles you selected by completing the Evaluation Table within the Critical Appraisal Tool Worksheet Template. Choose a total of four peer- reviewed articles that you selected related to your clinical topic of interest in Module 2 and Module 3.
Note: You can choose any combination of articles from Modules 2 and 3 for your Critical Appraisal. For example, you may choose two unfiltered research articles from Module 2 and two filtered research articles (systematic reviews) from Module 3 or one article from Module 2 and three articles from Module 3. You can choose any combination of articles from the prior Module Assignments as long as both modules and types of studies are represented.
Part 3B: Critical Appraisal of Research
Based on your appraisal, in a 1-2-page critical appraisal, suggest a best practice that emerges from the research you reviewed. Briefly explain the best practice, justifying your proposal with APA citations of the research.
BY DAY 7 OF WEEK 7
Submit Part 3A and 3B of your Evidence-Based Project. To Prepare:
Reflect on the four peer-reviewed articles you selected in Module 2 and the four systematic reviews (or other filtered high- level evidence) you selected in Module 3.
Reflect on the four peer-reviewed articles you selected in Module 2 and analyzed in Module 3.
Review and download the Critical Appraisal Tool Worksheet Template provided in the Resources.
The Assignment (Evidence-Based Project)
Part 3A: Critical Appraisal of Research
Conduct a critical appraisal of the four peer-reviewed articles you selected by completing the Evaluation Table within the Critical Appraisal Tool Worksheet Template. Choose a total of four peer- reviewed articles that you selected related to your clinical topic of interest in Module 2 and Module 3.
Note: You can choose any combination of articles from Modules 2 and 3 for your Critical Appraisal. For example, you may choose two unfiltered research articles from Module 2 and two filtered research articles (systematic reviews) from Module 3 or one article from Module 2 and three articles from Module 3. You can choose any combination of articles from the prior Module Assignments as long as both modules and types of studies are represented.
Part 3B: Critical Appraisal of Research
Based on your appraisal, in a 1-2-page critical appraisal, suggest a best practice that emerges from the research you reviewed. Briefly explain the best practice, justifying your proposal with APA citations of the research.
BY DAY 7 OF WEEK 7
Submit Part 3A and 3B of your Evidence-Based Project. To Prepare:
Reflect on the four peer-reviewed articles you selected in Module 2 and the four systematic reviews (or other filtered high- level evidence) you selected in Module 3.
Reflect on the four peer-reviewed articles you selected in Module 2 and analyzed in Module 3.
Review and download the Critical Appraisal Tool Worksheet Template provided in the Resources.
The Assignment (Evidence-Based Project)
Part 3A: Critical Appraisal of Research
Conduct a critical appraisal of the four peer-reviewed articles you selected by completing the Evaluation Table within the Critical Appraisal Tool Worksheet Template. Choose a total of four peer- reviewed articles that you selected related to your clinical topic of interest in Module 2 and Module 3.
Note: You can choose any combination of articles from Modules 2 and 3 for your Critical Appraisal. For example, you may choose two unfiltered research articles from Module 2 and two filtered research articles (systematic reviews) from Module 3 or one article from Module 2 and three articles from Module 3. You can choose any combination of articles from the prior Module Assignments as long as both modules and types of studies are represented.
Part 3B: Critical Appraisal of Research
Based on your appraisal, in a 1-2-page critical appraisal, suggest a best practice that emerges from the research you reviewed. Briefly explain the best practice, justifying your proposal with APA citations of the research.
BY DAY 7 OF WEEK 7
Submit Part 3A and 3B of your Evidence-Based Project.
Articles to use: 
May, F. N. J., Rees, M. T., Griffin, S., & Fildes, J. E. (2021). Understanding immunological response to desensitisation strategies in highly sensitised potential kidney transplant patients. Transplantation Reviews, 35(2). https://doi.org/10.1016/j.trre.2021.100596May, F. N. J., Rees, M. T., Griffin, S., & Fildes, J. E. (2021). Understanding immunological response to desensitisation strategies in highly sensitised potential kidney transplant patients. Transplantation Reviews, 35(2). https://doi.org/10.1016/j.trre.2021.100596May, F. N. J., Rees, M. T., Griffin, S., & Fildes, J. E. (2021). Understanding immunological response to desensitisation strategies in highly sensitised potential kidney transplant patients. Transplantation Reviews, 35(2). https://doi.org/10.1016/j.trre.2021.100596May, F. N. J., Rees, M. T., Griffin, S., & Fildes, J. E. (2021). Understanding immunological response to desensitisation strategies in highly sensitised potential kidney transplant patients. Transplantation Reviews, 35(2). https://doi.org/10.1016/j.trre.2021.100596
Fernández Rivera, C., Rodríguez Magariños, C., Calvo Rodríguez, M., Ferreiro Hermida, T., Blanco Pardo, M., López Muñiz, A., Erráez Guerrero, S., García Gago, L., & Alonso Hernández, Á. (2022). Low Incidence of Acute Antibody-Mediated Rejection after HLA Desensitization in Living Donor Kidney Transplant Recipients. Life (2075-1729), 12(12), 1993. https://doi.org/10.3390/life12121993Fernández Rivera, C., Rodríguez Magariños, C., Calvo Rodríguez, M., Ferreiro Hermida, T., Blanco Pardo, M., López Muñiz, A., Erráez Guerrero, S., García Gago, L., & Alonso Hernández, Á. (2022). Low Incidence of Acute Antibody-Mediated Rejection after HLA Desensitization in Living Donor Kidney Transplant Recipients. Life (2075-1729), 12(12), 1993. https://doi.org/10.3390/life12121993Fernández Rivera, C., Rodríguez Magariños, C., Calvo Rodríguez, M., Ferreiro Hermida, T., Blanco Pardo, M., López Muñiz, A., Erráez Guerrero, S., García Gago, L., & Alonso Hernández, Á. (2022). Low Incidence of Acute Antibody-Mediated Rejection after HLA Desensitization in Living Donor Kidney Transplant Recipients. Life (2075-1729), 12(12), 1993. https://doi.org/10.3390/life12121993Fernández Rivera, C., Rodríguez Magariños, C., Calvo Rodríguez, M., Ferreiro Hermida, T., Blanco Pardo, M., López Muñiz, A., Erráez Guerrero, S., García Gago, L., & Alonso Hernández, Á. (2022). Low Incidence of Acute Antibody-Mediated Rejection after HLA Desensitization in Living Donor Kidney Transplant Recipients. Life (2075-1729), 12(12), 1993. https://doi.org/10.3390/life12121993
Noble, J., Jouve, T., Malvezzi, P., & Rostaing, L. (2023). Desensitization in Crossmatch-positive Kidney Transplant Candidates. Transplantation, 107(2), 351–360. https://doi.org/10.1097/TP.0000000000004279Noble, J., Jouve, T., Malvezzi, P., & Rostaing, L. (2023). Desensitization in Crossmatch-positive Kidney Transplant Candidates. Transplantation, 107(2), 351–360. https://doi.org/10.1097/TP.0000000000004279Noble, J., Jouve, T., Malvezzi, P., & Rostaing, L. (2023). Desensitization in Crossmatch-positive Kidney Transplant Candidates. Transplantation, 107(2), 351–360. https://doi.org/10.1097/TP.0000000000004279Noble, J., Jouve, T., Malvezzi, P., & Rostaing, L. (2023). Desensitization in Crossmatch-positive Kidney Transplant Candidates. Transplantation, 107(2), 351–360. https://doi.org/10.1097/TP.0000000000004279
Malvezzi, P., Jouve, T., Noble, J., & Rostaing, L. (2018). Desensitization in the Setting of HLA-Incompatible Kidney Transplant. EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 16(4), 367–375. https://doi.org/10.6002/ect.2017.0355Malvezzi, P., Jouve, T., Noble, J., & Rostaing, L. (2018). Desensitization in the Setting of HLA-Incompatible Kidney Transplant. EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 16(4), 367–375. https://doi.org/10.6002/ect.2017.0355Malvezzi, P., Jouve, T., Noble, J., & Rostaing, L. (2018). Desensitization in the Setting of HLA-Incompatible Kidney Transplant. EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 16(4), 367–375. https://doi.org/10.6002/ect.2017.0355Malvezzi, P., Jouve, T., Noble, J., & Rostaing, L. (2018). Desensitization in the Setting of HLA-Incompatible Kidney Transplant. EXPERIMENTAL AND CLINICAL TRANSPLANTATION, 16(4), 367–375. https://doi.org/10.6002/ect.2017.0355
The template that has to be used for this assignment is attached below

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