Involvement of Clearance Mechanisms in Alzheimer’s Disease and Cerebral Amyloid Angiopathy

This is mostly already written in the paper I am attaching. I am requesting the paper be slightly rewritten to meet certain requests I would like. There are already 7 references written but I need a few more and I need any of the new information that is going to be added to the revised paper to have them as in-text citations. The format for the paper should have an introduction providing background information on both Cerebral Amyloid Angiopathy and Alzheimer’s Disease including how they present clinically, the mutations and proteins that cause the disease. To clarify, the paper needs to be changed to not be focused on Hereditary Cerebral Amyloid Angiopathy (HCAA) but to focus on the broader disease Cerebral Amyloid Angiopathy (CAA). The clearance mechanisms should also be introduced which are astrocytes, the glymphatic system, and aquaporin 4. The body of the paper should be labeled with subsections which should be broken down as follows for example, CAA and AQP4 and it would contain information about the involvement of aquaporin 4 as a clearance mechanism in Cerebral Amyloid Angiopathy, then CAA and the Glympathic System, CAA and astrocytes, and the same with Alzheimer’s Disease such as: AD and AQP4, etc. The paragraph that is highlighted regarding astrocyte numbers decreasing in patients diagnosed with AD and HCA would need a reference but if one cannot be found or if the information seems incorrect it would just need to be changed to match what is correct such if the astrocytes actually delocalize from the blood vessels in patients with the disease, and it needs a reference. There should also be a paragraph introducing Hereditary Cerebral Amyloid Angiopathy (HCAA) which is a more specific type of disease under the category of CAA and should have a reference. The end of the paper should also have a conclusion section which should summarize the main points of the paper and include what the implications are for future research specifically, not change in diet or exercise but what clinical implications or what future researchers may focus on to possibly develop therapies such as gene therapies for particular mutations. 

Essentially, the paper needs some additional research added to lengthen it as well as have the information reorganized so that there is an introduction, subsections with the diseases and each clearance mechanism, with the diseases and mutations and their implcations clinically, as well as a section speaking on HCAA, then a conclusion. Some of the information regarding astrocytes and AQP4 that is highlighted needs a reference or to be changed to reflect more accurate information, and additional references need to be added and included as in-text citations to show where the information was obtained. Thank you for your hard work, if you have any questions or need clarifications please reach out to me any time.